Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology

Yılmaz  Güvercin; Ahmet Atilla  Abdioğlu; Mehmet Emre  Baki; Gökçen  Kerimoğlu; İlker  Karahasanoğlu; Mehmet  Yıldız

doi:10.5455/handmicrosurg.69020

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Original Article

Hand Microsurg. 2021; 10(3): 193-202

doi: 10.5455/handmicrosurg.69020

Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology

Yılmaz Güvercin, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gökçen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız.

Abstract
Objectives: In this study, optimal dose to reduce tendon adhesion, by using the dose-dependent fibroblast proliferation inhibition effect of Mit-C, and the level, which the tendon histologies are affected, using biomechanical stretching, is investigated.
Methods: 56 chicken flexor tendons were used in this study. A total of 9 groups were formed. Mit-C were applied between the tendon and the sheath; 0.9% NaCl for surgical control groups (groupII, groupIII), 0.1mg/ml Mit-C (groupIV, groupVII), 0.2mg/ml Mit-C (groupV, groupVIII) 0.5 mg/ml Mit-C (groupVI, groupIX). Macroscopic, microscopic, synovial sheath thickness and active fibroblast count were compared between the groups that underwent biomechanical stretching (groups III,V,VII,IX) and groups without biomechanical stretching (groups I,II,IV,VI,VIII).
Results: After the macroscopic and microscopic examination, it was observed that the groups with the most adhesion were surgical control groups. The best results from the experimental groups were seen in group VIII, but the results of the groups were similar. When active fibroblast count was examined, it was seen that group VIII had the least active fibroblast count.
Conclusion: According to the results of the evaluation, Mit-C, by inhibiting fibroblast proliferation and decreasing synovial sheath thickness, decreased adhesion formation. At the same time, it was concluded that the optimal dose for adhesion prevention was 0.2mg/ml, biomechanical stretching affected tendon histology and the drug was suitable for clinical studies.

Key words: Chicken, Mitomycin C, Tendon, Adhesion

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How to Cite this Article

Pubmed Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu �, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020

Web Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu �, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. https://handmicrosurgeryjournal.com/?mno=69020 [Access: September 13, 2024]. doi:10.5455/handmicrosurg.69020

AMA (American Medical Association) Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu �, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020

Vancouver/ICMJE Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu �, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. (2021), [cited September 13, 2024]; 10(3): 193-202. doi:10.5455/handmicrosurg.69020

Harvard Style

Guvercin, Y., Abdioğlu, A. A., Baki, M. E., Kerimoğlu, G., Karahasanoğlu, �., Yıldız, M. & (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020

Turabian Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . 2021. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020

Chicago Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10 (2021), 193-202. doi:10.5455/handmicrosurg.69020

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Guvercin, Y., Abdioğlu, A. A., Baki, M. E., Kerimoğlu, G., Karahasanoğlu, �., Yıldız, M. & (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020

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About Hand and Microsurgery Hand and Microsurgery, the official journal of Turkish Society for Surgery of Hand and Upper Extremity, is a peer-reviewed scientific journal published th ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information