A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report

Murat Sinan Engin; Yener Demirtas; Tale Neimetzade; Bulent Ayas; Ibrahim Alper Aksakal; Ahmet Karacalar

doi:10.5455/handmicrosurg.203541

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Original Article
Online Published: 25 Aug 2016

Hand Microsurg. 2016; 5(2): 62-69

doi: 10.5455/handmicrosurg.203541

A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar.

Abstract
Objectives: Treatments of long peripheral nerve defects are limited and a means to construct a vascularized nerve graft substitute has been sought.
Material and Methods: An in vivo chamber bioreactor was designed with the White New Zealand rabbits superficial inferior epigastric pedicle (SIEP) and using autologous Schwann cell (ASC) suspension, a tissue volume containing rich vascularization and a dense presence of Schwann cells was constructed. This construct was comparatively tried on 3 cm of a sciatic nerve defect.
Results: A vascularized build with rich blood supply and an abundance of Schwann cells was engineered and utilized for nerve regeneration and transmission, axonal passage being displayed.
Conclusion: According to the literature review, this is the first achievement of engineering a nerve graft substitute containing vascularized Schwann cells. Therefore, it is believed this study has yielded significant preliminary results, providing a basis for future studies.

Key words: Peripheral nerves, tissue engineering, autologous schwann cells, cell culture, vascularized nerve graft

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Pubmed Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg. 2016; 5(2): 62-69. doi:10.5455/handmicrosurg.203541

Web Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. https://handmicrosurgeryjournal.com/?mno=203541 [Access: September 12, 2024]. doi:10.5455/handmicrosurg.203541

AMA (American Medical Association) Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg. 2016; 5(2): 62-69. doi:10.5455/handmicrosurg.203541

Vancouver/ICMJE Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg. (2016), [cited September 12, 2024]; 5(2): 62-69. doi:10.5455/handmicrosurg.203541

Harvard Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar (2016) A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg, 5 (2), 62-69. doi:10.5455/handmicrosurg.203541

Turabian Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar. 2016. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand and Microsurgery, 5 (2), 62-69. doi:10.5455/handmicrosurg.203541

Chicago Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar. "A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report." Hand and Microsurgery 5 (2016), 62-69. doi:10.5455/handmicrosurg.203541

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar (2016) A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand and Microsurgery, 5 (2), 62-69. doi:10.5455/handmicrosurg.203541

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About Hand and Microsurgery Hand and Microsurgery, the official journal of Turkish Society for Surgery of Hand and Upper Extremity, is a peer-reviewed scientific journal published th ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information