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Online Published: 25 Aug 2016
 


A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar.


Abstract
Objectives: Treatments of long peripheral nerve defects are limited and a means to construct a vascularized nerve graft substitute has been sought.
Material and Methods: An in vivo chamber bioreactor was designed with the White New Zealand rabbit’s superficial inferior epigastric pedicle (SIEP) and using autologous Schwann cell (ASC) suspension, a tissue volume containing rich vascularization and a dense presence of Schwann cells was constructed. This construct was comparatively tried on 3 cm of a sciatic nerve defect.
Results: A vascularized build with rich blood supply and an abundance of Schwann cells was engineered and utilized for nerve regeneration and transmission, axonal passage being displayed.
Conclusion: According to the literature review, this is the first achievement of engineering a nerve graft substitute containing vascularized Schwann cells. Therefore, it is believed this study has yielded significant preliminary results, providing a basis for future studies.

Key words: Peripheral nerves, tissue engineering, autologous schwann cells, cell culture, vascularized nerve graft


 
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How to Cite this Article
Pubmed Style

Engin MS, Demirtas Y, Neimetzade T, Ayas B, Aksakal IA, Karacalar A. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg. 2016; 5(2): 62-69. doi:10.5455/handmicrosurg.203541

Web Style

Engin MS, Demirtas Y, Neimetzade T, Ayas B, Aksakal IA, Karacalar A. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. https://handmicrosurgeryjournal.com/?mno=203541 [Access: June 27, 2026]. doi:10.5455/handmicrosurg.203541

AMA (American Medical Association) Style

Engin MS, Demirtas Y, Neimetzade T, Ayas B, Aksakal IA, Karacalar A. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg. 2016; 5(2): 62-69. doi:10.5455/handmicrosurg.203541


Vancouver/ICMJE Style

Engin MS, Demirtas Y, Neimetzade T, Ayas B, Aksakal IA, Karacalar A. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg. (2016), [cited June 27, 2026]; 5(2): 62-69. doi:10.5455/handmicrosurg.203541


Harvard Style

Engin, M. S., Demirtas, . Y., Neimetzade, . T., Ayas, . B., Aksakal, . I. A. & Karacalar, . A. (2016) A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand Microsurg, 5 (2), 62-69. doi:10.5455/handmicrosurg.203541


Turabian Style

Engin, Murat Sinan, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, and Ahmet Karacalar. 2016. A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand and Microsurgery, 5 (2), 62-69. doi:10.5455/handmicrosurg.203541


Chicago Style

Engin, Murat Sinan, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, and Ahmet Karacalar. "A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report." Hand and Microsurgery 5 (2016), 62-69. doi:10.5455/handmicrosurg.203541


MLA (The Modern Language Association) Style

Engin, Murat Sinan, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, and Ahmet Karacalar. "A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report." Hand and Microsurgery 5.2 (2016), 62-69. Print. doi:10.5455/handmicrosurg.203541


APA (American Psychological Association) Style

Engin, M. S., Demirtas, . Y., Neimetzade, . T., Ayas, . B., Aksakal, . I. A. & Karacalar, . A. (2016) A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report. Hand and Microsurgery, 5 (2), 62-69. doi:10.5455/handmicrosurg.203541




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    About Hand and Microsurgery

    Hand and Microsurgery, the official journal of Turkish Society for Surgery of Hand and Upper Extremity, is a peer-reviewed scientific journal published th ... Read more.



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