Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Article 


Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology

Yılmaz Güvercin, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gökçen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız.

Abstract
Objectives: In this study, optimal dose to reduce tendon adhesion, by using the dose-dependent fibroblast proliferation inhibition effect of Mit-C, and the level, which the tendon histologies are affected, using biomechanical stretching, is investigated.
Methods: 56 chicken flexor tendons were used in this study. A total of 9 groups were formed. Mit-C were applied between the tendon and the sheath; 0.9% NaCl for surgical control groups (groupII, groupIII), 0.1mg/ml Mit-C (groupIV, groupVII), 0.2mg/ml Mit-C (groupV, groupVIII) 0.5 mg/ml Mit-C (groupVI, groupIX). Macroscopic, microscopic, synovial sheath thickness and active fibroblast count were compared between the groups that underwent biomechanical stretching (groups III,V,VII,IX) and groups without biomechanical stretching (groups I,II,IV,VI,VIII).
Results: After the macroscopic and microscopic examination, it was observed that the groups with the most adhesion were surgical control groups. The best results from the experimental groups were seen in group VIII, but the results of the groups were similar. When active fibroblast count was examined, it was seen that group VIII had the least active fibroblast count.
Conclusion: According to the results of the evaluation, Mit-C, by inhibiting fibroblast proliferation and decreasing synovial sheath thickness, decreased adhesion formation. At the same time, it was concluded that the optimal dose for adhesion prevention was 0.2mg/ml, biomechanical stretching affected tendon histology and the drug was suitable for clinical studies.

Key words: Chicken, Mitomycin C, Tendon, Adhesion


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Yılmaz Güvercin
Articles by Ahmet Atilla Abdioğlu
Articles by Mehmet Emre Baki
Articles by Gökçen Kerimoğlu
Articles by İlker Karahasanoğlu
Articles by Mehmet Yıldız
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020


Web Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. http://handmicrosurgeryjournal.com/?mno=69020 [Access: December 26, 2021]. doi:10.5455/handmicrosurg.69020


AMA (American Medical Association) Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020



Vancouver/ICMJE Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. (2021), [cited December 26, 2021]; 10(3): 193-202. doi:10.5455/handmicrosurg.69020



Harvard Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız| (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020



Turabian Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. 2021. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020



Chicago Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10 (2021), 193-202. doi:10.5455/handmicrosurg.69020



MLA (The Modern Language Association) Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız|. "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10.3 (2021), 193-202. Print. doi:10.5455/handmicrosurg.69020



APA (American Psychological Association) Style

Yılmaz Güvercin|Ahmet Atilla Abdioğlu|Mehmet Emre Baki|Gökçen Kerimoğlu|İlker Karahasanoğlu|Mehmet Yıldız| (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


DOAJ (Directory of Open Access Journals)

EuroPub Database

Hinari (World Health Organization)

Ulakbim

ScopeMed

Google Scholar

WordCat

 

 


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Hand and Microsurgery are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.