ISSN 2458-7834
 

Original Article 


Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology

Yılmaz Güvercin, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gökçen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız.

Abstract
Objectives: In this study, optimal dose to reduce tendon adhesion, by using the dose-dependent fibroblast proliferation inhibition effect of Mit-C, and the level, which the tendon histologies are affected, using biomechanical stretching, is investigated.
Methods: 56 chicken flexor tendons were used in this study. A total of 9 groups were formed. Mit-C were applied between the tendon and the sheath; 0.9% NaCl for surgical control groups (groupII, groupIII), 0.1mg/ml Mit-C (groupIV, groupVII), 0.2mg/ml Mit-C (groupV, groupVIII) 0.5 mg/ml Mit-C (groupVI, groupIX). Macroscopic, microscopic, synovial sheath thickness and active fibroblast count were compared between the groups that underwent biomechanical stretching (groups III,V,VII,IX) and groups without biomechanical stretching (groups I,II,IV,VI,VIII).
Results: After the macroscopic and microscopic examination, it was observed that the groups with the most adhesion were surgical control groups. The best results from the experimental groups were seen in group VIII, but the results of the groups were similar. When active fibroblast count was examined, it was seen that group VIII had the least active fibroblast count.
Conclusion: According to the results of the evaluation, Mit-C, by inhibiting fibroblast proliferation and decreasing synovial sheath thickness, decreased adhesion formation. At the same time, it was concluded that the optimal dose for adhesion prevention was 0.2mg/ml, biomechanical stretching affected tendon histology and the drug was suitable for clinical studies.

Key words: Chicken, Mitomycin C, Tendon, Adhesion


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Yılmaz Güvercin
Articles by Ahmet Atilla Abdioğlu
Articles by Mehmet Emre Baki
Articles by Gökçen Kerimoğlu
Articles by İlker Karahasanoğlu
Articles by Mehmet Yıldız
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu , Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020


Web Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu , Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. https://handmicrosurgeryjournal.com/?mno=69020 [Access: May 27, 2022]. doi:10.5455/handmicrosurg.69020


AMA (American Medical Association) Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu , Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020



Vancouver/ICMJE Style

Guvercin Y, Abdioğlu AA, Baki ME, Kerimoğlu G, Karahasanoğlu , Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. (2021), [cited May 27, 2022]; 10(3): 193-202. doi:10.5455/handmicrosurg.69020



Harvard Style

Guvercin, Y., Abdioğlu, A. A., Baki, M. E., Kerimoğlu, G., Karahasanoğlu, ., Yıldız, M. & (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020



Turabian Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . 2021. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020



Chicago Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10 (2021), 193-202. doi:10.5455/handmicrosurg.69020



MLA (The Modern Language Association) Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10.3 (2021), 193-202. Print. doi:10.5455/handmicrosurg.69020



APA (American Psychological Association) Style

Guvercin, Y., Abdioğlu, A. A., Baki, M. E., Kerimoğlu, G., Karahasanoğlu, ., Yıldız, M. & (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020





Most Viewed Articles
  • Giant intramuscular lipoma of arm: A case report and review of the literature
    Muzaffer Durmus, Ahmet Demirhan Dal, Abdul Kerim Yapici, Sedat Avsar, Yalcin Bayram
    Hand Microsurg. 2014; 3(3): 87-90
    » Abstract & References » doi: 10.5455/handmicrosurg.173820

  • Cubital tunnel syndrome due to heterotrophic ossification caused by radial head fracture: A case report
    Seyitali Gumustas, Haci Bayram Tosun, Ismail Agir, Abuzer Uludag
    Hand Microsurg. 2014; 3(1): 24-28
    » Abstract & References » doi: 10.5455/handmicrosurg.1577

  • Munchausen’s syndrome or pure self-mutilation? A case of self-inflicted tendon injury
    Burak Kaya, Servet Elcin Alpat, Mehmet Sonmez, Cem Cerkez, Savas Serel
    Hand Microsurg. 2014; 3(3): 83-86
    » Abstract & References » doi: 10.5455/handmicrosurg.172607

  • Radial nerve grafting in high energy humeral fractures
    Yusuf Gürbüz, Tahir Sadık Sügün, Kemal Özaksar, Murat Kayalar, Tulgar Toros, İbrahim Kaplan
    Hand Microsurg. 2012; 1(2): 60-64
    » Abstract & References » doi: 10.2399/emd.12.58077

  • The utility of onion extract gel containing topical allantoin and heparin after surgical treatment of upper extremity burn scars
    Mehmet Ihsan Okur, Alpagan Mustafa Yildirim, Bilsev Ince
    Hand Microsurg. 2014; 3(3): 74-79
    » Abstract & References » doi: 10.5455/handmicrosurg.172436

  • Most Downloaded
  • Bone island and hand involvement – A short review
    Ganesh Singh Dharmshaktu, Binit Singh
    Hand Microsurg. 2018; 7(2): 93-97
    » Abstract » doi: 10.5455/handmicrosurg.258665

  • Lipofibromatous hamartoma of the digital nerve: A case report
    Emin Sir, Alper Aksoy
    Hand Microsurg. 2018; 7(1): 45-48
    » Abstract » doi: 10.5455/handmicrosurg.255406

  • The three bony point relationship of the elbow-Why is there still a lack of consensus?
    Supreeth Nekkanti, Dama Kondaiah Naidu, Jasmine Sebastin, Kamal Prasad, Mohan Yeshwanth, Archana Meka
    Hand Microsurg. 2018; 7(2): 79-82
    » Abstract » doi: 10.5455/handmicrosurg.291476

  • Hand grip strength: Age and gender stratified normative data in Anatolian population
    Melih Unal, Ozkan Kose, Hasan Onur Arik, Ferhat Guler, Baver Acar, Halil Yalcin Yuksel
    Hand Microsurg. 2018; 7(1): 16-23
    » Abstract » doi: 10.5455/handmicrosurg.257058

  • Synovial chondromatosis of the wrist
    Murat Kayalar, Abuzer Uludag, Basak Doganavsargil Yakut, Ahmet Savran
    Hand Microsurg. 2018; 7(2): 109-111
    » Abstract » doi: 10.5455/handmicrosurg.269392

  • Most Cited Articles
  • The rise of wide awake hand surgery - Contribution from Turkey
    Egemen Ayhan, Emre Ozdemir, Ender Gumusoglu, Kadir Cevik, Metin M Eskandari
    Hand Microsurg. 2018; 7(3): 125-134
    » Abstract » doi: 10.5455/handmicrosurg.299709
    Cited : 6 times [Click to see citing articles]

  • Giant lipomas of the hand
    Gokce Yildiran, Osman Akdag, Mehtap Karamese, Muhammed Nebil Selimoglu, Zekeriya Tosun
    Hand Microsurg. 2015; 4(1): 8-11
    » Abstract & References » doi: 10.5455/handmicrosurg.175443
    Cited : 3 times [Click to see citing articles]

  • Upper extremity tumors
    Levent Eralp , Halil Buldu
    Hand Microsurg. 2013; 2(3): 105-114
    » Abstract & References » doi: 10.5455/handmicrosurg.164446
    Cited : 3 times [Click to see citing articles]

  • Flexor pollicis longus repair in a patient with Linburg-Comstock anomaly: A case report
    Mehmet Unal, Eren Cansu, Hakan Cift
    Hand Microsurg. 2016; 5(2): 88-91
    » Abstract » doi: 10.5455/handmicrosurg.193633
    Cited : 3 times [Click to see citing articles]

  • Hirudo medicinalis - historical and biological background and their role in microsurgery: Review article
    Abdul Kerim Yapici, Muzaffer Durmus, Mehmet Tanyuksel, Selim Turkkan, Harun Yasin Tuzun, Arsen Arsenishvili
    Hand Microsurg. 2017; 6(1): 34-38
    » Abstract » doi: 10.5455/handmicrosurg.217838
    Cited : 3 times [Click to see citing articles]