ISSN 2458-7834
 

Original Article 


Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology

Yılmaz Güvercin, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gökçen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız.

Abstract
Objectives: In this study, optimal dose to reduce tendon adhesion, by using the dose-dependent fibroblast proliferation inhibition effect of Mit-C, and the level, which the tendon histologies are affected, using biomechanical stretching, is investigated.
Methods: 56 chicken flexor tendons were used in this study. A total of 9 groups were formed. Mit-C were applied between the tendon and the sheath; 0.9% NaCl for surgical control groups (groupII, groupIII), 0.1mg/ml Mit-C (groupIV, groupVII), 0.2mg/ml Mit-C (groupV, groupVIII) 0.5 mg/ml Mit-C (groupVI, groupIX). Macroscopic, microscopic, synovial sheath thickness and active fibroblast count were compared between the groups that underwent biomechanical stretching (groups III,V,VII,IX) and groups without biomechanical stretching (groups I,II,IV,VI,VIII).
Results: After the macroscopic and microscopic examination, it was observed that the groups with the most adhesion were surgical control groups. The best results from the experimental groups were seen in group VIII, but the results of the groups were similar. When active fibroblast count was examined, it was seen that group VIII had the least active fibroblast count.
Conclusion: According to the results of the evaluation, Mit-C, by inhibiting fibroblast proliferation and decreasing synovial sheath thickness, decreased adhesion formation. At the same time, it was concluded that the optimal dose for adhesion prevention was 0.2mg/ml, biomechanical stretching affected tendon histology and the drug was suitable for clinical studies.

Key words: Chicken, Mitomycin C, Tendon, Adhesion


 
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How to Cite this Article
Pubmed Style

Guvercin Y, AbdioÄŸlu AA, Baki ME, KerimoÄŸlu G, KarahasanoÄŸlu Ä, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020


Web Style

Guvercin Y, AbdioÄŸlu AA, Baki ME, KerimoÄŸlu G, KarahasanoÄŸlu Ä, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. https://handmicrosurgeryjournal.com/?mno=69020 [Access: January 10, 2024]. doi:10.5455/handmicrosurg.69020


AMA (American Medical Association) Style

Guvercin Y, AbdioÄŸlu AA, Baki ME, KerimoÄŸlu G, KarahasanoÄŸlu Ä, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. 2021; 10(3): 193-202. doi:10.5455/handmicrosurg.69020



Vancouver/ICMJE Style

Guvercin Y, AbdioÄŸlu AA, Baki ME, KerimoÄŸlu G, KarahasanoÄŸlu Ä, Yıldız M, . Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg. (2021), [cited January 10, 2024]; 10(3): 193-202. doi:10.5455/handmicrosurg.69020



Harvard Style

Guvercin, Y., AbdioÄŸlu, A. A., Baki, M. E., KerimoÄŸlu, G., KarahasanoÄŸlu, Ä., Yıldız, M. & (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand Microsurg, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020



Turabian Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . 2021. Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020



Chicago Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10 (2021), 193-202. doi:10.5455/handmicrosurg.69020



MLA (The Modern Language Association) Style

Guvercin, Yılmaz, Ahmet Atilla Abdioğlu, Mehmet Emre Baki, Gokcen Kerimoğlu, İlker Karahasanoğlu, Mehmet Yıldız, and . "Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology." Hand and Microsurgery 10.3 (2021), 193-202. Print. doi:10.5455/handmicrosurg.69020



APA (American Psychological Association) Style

Guvercin, Y., AbdioÄŸlu, A. A., Baki, M. E., KerimoÄŸlu, G., KarahasanoÄŸlu, Ä., Yıldız, M. & (2021) Effect Of Mitomycin C in The Prevention of Tendon Adhesion After Surgery and The Effect of Biomechanical Stretching on Tendon Histology. Hand and Microsurgery, 10 (3), 193-202. doi:10.5455/handmicrosurg.69020





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